Glycogen synthase kinase-3b is a serine/threonine kinase that has recently emerged as a key target for neurodegenerative diseases and diabetes. As an initial step of our lead discovery program we ...

Substantial progress in virtual screening requires a profound understanding of the forces that govern protein folding and the dynamics of macromolecular complex formation. First, and most importantly, ...

Virtual screening uses computer-based methods to discover new ligands on the basis of biological structures. Although widely heralded in the 1970s and 1980s, the technique has since struggled to meet ...